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Titre du Document
Methoxy Polyethylene Glycol-Epoetin Beta : A Review of its Use in the Management of Anaemia Associated with Chronic Kidney Disease
Auteur(s)
CURRAN Monique P. ; MCCORMACK Paul L.
Résumé
Methoxy polyethylene glycol-epoetin beta (Mircera®) is a continuous erythropoietin receptor activator, with a long half-life (approximately 130 hours). In patients with anaemia associated with chronic kidney disease (CKD), both on and not on dialysis, who had not previously received an erythropoiesis-stimulating agent (ESA), methoxy polyethylene glycol-epoetin beta administered intravenously or subcutaneously once every 2 weeks resulted in a smooth and steady rise in haemoglobin levels. The response rates were high (up to 97.5%) in these patients at the end of the correction period; response rates with the comparator ESAs (epoetin alfa or beta, or darbepoetin alfa) were up to 96.3%. Moreover, patients with CKD on dialysis who had previously been treated with an ESA maintained stable haemoglobin levels (within ±1 g/dL of baseline and within a range of 10-13.5 g/dL) when directly converted to methoxy polyethylene glycol-epoetin beta administered intravenously or subcutaneously once every 2 or 4 weeks. Methoxy polyethylene glycol-epoetin beta is generally well tolerated, with most adverse events being of mild to moderate severity, consistent with the co-morbidities known to occur in this patient group and those reported with other ESAs. In conclusion, in patients with anaemia associated with CKD, subcutaneous or intravenous methoxy polyethylene glycol-epoetin beta achieved a high haemoglobin response rate (ESA-naive patients) when administered once every 2 weeks and maintained
Editeur
Adis International
Identifiant
PMID : 18484803 ISSN : 0012-6667 CODEN : DRUGAY
Source
Drugs (Basel) A. 2008, vol. 68, n° 8, pp. 1139-1156 [18 pages] [bibl. : 66 ref.]
Langue
Anglais
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