Détail de la notice
Titre du Document
Preparation and evaluation of self-microemulsifying drug delivery systems (SMEDDS) containing atorvastatin
Auteur(s)
HAIRONG SHEN ; MINGKANG ZHONG
Résumé
Atorvastatin is insoluble in aqueous solution and the bioavailability after oral administration is low. Self-microemulsifying drug delivery systems (SMEDDS) containing atorvastatin have been successfully prepared to improve its bioavailability. SMEDDS is a mixture of lipid, surfactant, and cosurfactant, which are emulsified in aqueous medium under gentle digestive motility in the gastrointestinal tract. Pseudo-ternary phase diagrams composed of various excipients were plotted. Droplet size, zeta-potential and long-term physical stability of the formulations were investigated. The release of atorvastatin from SMEDDS capsules was studied using the dialysis bag method in 0.1 M HCI and phosphate buffer (pH 7.4), compared with the release of atorvastatin from a conventional tablet. A pharmacokinetic study was performed in 6 beagle dogs after oral administration of 6 mg kg-1 atorvastatin. The bioavailability of atorvastatin SMEDDS capsules was significantly increased compared with that of the conventional tablet. SMEDDS capsules consisting of Labrafil, propylene glycol and Cremophor RH40 provided the greatest bioavailability. Our studies indicate that the use of SMEDDS for the delivery of atorvastatin can improve its bioavailability.
Editeur
Pharmaceutical Press
Identifiant
ISSN : 0022-3573 CODEN : JPPMAB
Source
Journal of pharmacy and pharmacology A. 2006, vol. 58, n° 9, pp. 1183-1191 [9 pages]
Langue
Anglais
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