Détail de la notice
Titre du Document
Seasonality effects on schizophrenic births in multiplex families in a tropical island
Auteur(s)
CARRION-BARALT Jose R. ; SMITH Christopher J. ; ROSSY-FULLANA Enrique ; ...
Résumé
Many studies have found that individuals with schizophrenia have been born in winter months in disproportionately high numbers. Temperature and weather effects, such as hot summers or cold winters, have been among the suggested explanations for this seasonality effect. We studied the relationship between schizophrenia and season of birth in Puerto Rico, a tropical island with mild seasonal variation of temperature and virtually no cold periods. Our sample consisted of 132 subjects (57 with schizophrenia, 75 without) from 24 multiplex families. Schizophrenic family members were significantly more likely to be born during the winter months (21/57; 36.8%) than their unaffected relatives (16/75; 21.3%). These results suggest that extreme temperatures are not a sufficient explanation for the seasonality effect and that other factors associated with seasonality may have an effect on the later development of schizophrenia. The fact that a seasonality effect was found in a group likely to have an increased genetic loading for schizophrenia suggests that seasonality may be associated with a second, environmental "hit" in a "two-hit hypothesis" of schizophrenia.
Editeur
Elsevier
Identifiant
PMID : 16516305 ISSN : 0165-1781 CODEN : PSRSDR
Source
Psychiatry research A. 2006, vol. 142, n° 1, pp. 93-97 [5 pages] [bibl. : 10 ref.]
Langue
Anglais
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