Détail de la notice
Titre du Document
Long-term changes in blood-brain barrier permeability and white matter following prolonged systemic inflammation in early development in the rat
Auteur(s)
STOLP H. B. ; DZIEGIELEWSKA K. M. ; EK C. J. ; ...
Résumé
Epidemiological evidence in human fetuses links inflammation during development with white matter damage. Breakdown of the blood-brain barrier has been proposed as a possible mechanism. This was investigated in the present study by inducing a prolonged inflammatory response in newborn rats, with intraperitoneal injections of lipopolysaccharide (LPS; 0.2 mg/kg) given at postnatal (P) day 0, P2, P4, P6 and P8. An acute phase response was present over the whole period of injections. Changes in blood-brain barrier permeability were determined for small (sucrose and inulin) and large (protein) molecules. During and immediately after the inflammatory response, plasma proteins were detected in the brain only within white matter tracts, indicating an increased permeability of the blood-brain barrier to protein during this period. The alteration in permeability to protein was transient. In contrast, the permeability of the blood-brain barrier to 14C-sucrose and 14C-inulin was significantly higher in adult animals that had received serial LPS injections during development. Adult animals receiving a single 1 mg/kg LPS injection at P0 showed no alteration in blood-brain barrier permeability to either small or larger molecules. A significant decrease in the volume of CNPase immunoreactive presumptive white matter tracts occurred in the external capsule and corpus callosum at P9. These results demonstrate that a prolonged systemic inflammatory response in the early
Editeur
Blackwell
Identifiant
PMID : 16324115 ISSN : 0953-816X
Source
European journal of neuroscience (Print) A. 2005, vol. 22, n° 11, pp. 2805-2816 [12 pages]
Langue
Anglais
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