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Titre du Document
The prevalence of prostate carcinoma and its precursor in Hungary : An autopsy study
Auteur(s)
SOOS Gyorgyike ; TSAKIRIS Ioannis ; SZANTO Janos ; ...
Résumé
Objectives: The prevalence of incidental prostatic adenocarcinoma (PCa) and its precursor, high grade intraepithelial neoplasia (HGPIN) in an autopsy series from Hungarians (Central European Caucasians) was assessed and compared to similar data from the United States and European countries. Methods: Autopsy cases (n = 139; 18-95 years) with no history of urological disease were histologically examined for prostate cancer and HGPIN. After en block removal, the prostate glands were fixed in formalin, sectioned at 3-5 mm intervals and embedded in paraffin. Whole-mount serial sections were stained with Hematoxylin-eosin and examined for the presence of PCa and HGPIN. The frequency of PCa and HGPIN was compared to autopsy data obtained from other geographical areas. Results: We found a 38.8% prevalence of incidental PCa with increasing age-related incidence. Both PCa and HGPIN are first detected in the 3rd decade and show a steady increase with age with respect to number of foci, tumor grade and volume. In the age group 81-95, 86.6% and 60% of men had PCa and HGPIN, respectively. Conclusions: Incidental PCa and HGPIN are very prevalent in Hungarian population, comparable with the high US and the Scandinavian epidemiological data for Caucasians.
Editeur
Elsevier
Identifiant
PMID : 16203079 ISSN : 0302-2838 CODEN : EUURAV
Source
European urology A. 2005, vol. 48, n° 5, pp. 739-744 [6 pages] [bibl. : 42 ref.]
Langue
Anglais
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