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Titre du Document
Acetyl salicylic acid (ASPIRIN) increases the CD4+ T lymphocytes and suppresses TNF-a in HIV-I infected patients: Results of a 12 month, three-arm, placebo-controlled pilot study
Auteur(s)
ELOPY NIMELE SIBANDA ; STANZUK Grazyna A. ; THOMSEN Marianne ; ...
Résumé
The aim of this pilot study was to investigate the use of aspirin in the management of HIV disease. It is three-arm, placebo controlled 6-month crossover study with a 12 months patient follow-up. Anti-retroviral naive HIV-1 infected patients with a CD4+ T lymphocyte count greater than 150 cells/ml were enrolled and randomized into 3 groups, which received (a) the placebo, (b) Acetyl-salicylic acid (aspirin) 300 mg four times a day and (c) chloroquine150 mg thrice a day. Thirty-one of 52 HIV+ volunteers fuelled the enrolment criteria. The body mass, CD4+/CD8+ counts, HIV viral load, p24 antigen levels and complete blood counts (CBC) were measured at baseline and three-monthly. Plasma levels of the cytokines IL-2, IL-4, IL-6 and TNF-a were measured at baseline and after 6 months. Twenty-four participants had complete paired CD4 and viral load data, of these 7 were in the placebo arm, 10 in the aspirin/chloroquine arm and 7 in the aspirin arm. There was an increase (p<0.05) in both body mass and haemoglobin levels. In the placebo arm, the median CD4+ T lymphocyte count decreased from a baseline of 258 to 216 cells (16%) [p=0.038] in 24 weeks but doubled to 471 (46%) [p=0.075] a mere 12 weeks after the patients were crossed over to the aspirin arm. In the aspirin treated group, the CD4 count increased by 23.3% from a mean baseline of 363 after 24 weeks [p=0.0]5] to 665 after 36 weeks [p=0.078 by the Wilcoxon rank test] followed by a statistically insignificant drop to 495 after 1
Editeur
Research signpost
Identifiant
ISSN : ISBN : 81-7736-112-0
Source
A. 2004, pp. 179-190 [12 pages] [bibl. : 38 ref.]
Langue
Anglais
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