Détail de la notice
Titre du Document
Addiction, a condition of compulsive behaviour? neuroimaging and neuropsychological evidence of inhibitory dysregulation. Commentaries
Auteur(s)
LUBMAN Dan I. ; YÜCEL Murat ; PANTELIS Christos ; ...
Résumé
Aims Addiction has been conceptualized as a shift from controlled experimentation to uncontrolled, compulsive patterns of use. Current neurobiological models of addiction emphasize changes within the brain's reward system, such that drugs of abuse 'hijack' this system and bias behaviour towards further drug use. While this model explains the involuntary nature of craving and the motivational drive to continue drug use, it does not explain fully why some addicted individuals are unable to control their drug use when faced with potentially disastrous consequences. In this review, we argue that such maladaptive and uncontrolled behaviour is underpinned by a failure of the brain's inhibitory control mechanisms. Design Relevant neuroimaging, neuropsychological and clinical studies are reviewed, along with data from our own research. Findings The current literature suggests that in addition to the brain's reward system, two frontal cortical regions (anterior cingulate and orbitofrontal cortices), critical in inhibitory control over reward-related behaviour, are dysfunctional in addicted individuals. These same regions have been implicated in other compulsive conditions characterized by deficits in inhibitory control over maladaptive behaviours, such as obsessive-compulsive disorder. Conclusions We propose that in chronically addicted individuals, maladaptive behaviours and high relapse rates may be better conceptualized as being 'compulsive' in nature as a result of dysfunction wit
Editeur
Blackwell
Identifiant
PMID : 15585037 ISSN : 0965-2140
Source
Addiction (Abingdon. Print) A. 2004, vol. 99, n° 12, pp. 1491-1507 [17 pages] [bibl. : 3 p.3/4]
Langue
Anglais
Pour les membres de la communauté du CNRS, ce document est autorisé à la reproduction à titre gratuit.
Pour les membres des communautés hors CNRS, la reproduction de ce document à titre onéreux sera fournie sous réserve d’autorisation du Centre Français d’exploitation du droit de Copie.

Pour bénéficier de nos services (strictement destinés aux membres de la communauté CNRS (Centre National de la Recherche Scientifique), de l'ESR français (Enseignement Supérieur et Recherche), et du secteur public français & étranger) :