Détail de la notice
Titre du Document
Comparison of in vivo (draize method) and in vitro (corrositex assay) dermal corrosion values for selected industrial chemicals
Auteur(s)
STOBBE Jody L. ; DRAKE Kevin D. ; MAIER Kurt J.
Résumé
Skin irritation is a common occupational hazard for employees engaged in the manufacture, transport, and use of industrial chemicals. The most common method used to evaluate dermal irritation and/or corrosion has typically been in vivo tests using rabbits (Draize method). Several in vitro test methods have been developed, with Corrositex being the first to gain approval by a regulatory agency (U.S. Department of Transportation). The purpose of this study was to compare the results of in vitro (Corrositex) assays of dermal irritation/corrosion to in vivo test data for several industrial chemical formulations and to determine the predictability and usefulness of the Corrositex assay for these types of products. Twenty-four (24) formulations were qualified, categorized, and evaluated using the Corrositex method and the results compared to available animal data for each of the formulations. The Corrositex assay accurately predicted a corrosive end point in 8 (57.1%) of the 14 formulations identified as corrosive by the in vivo evaluations. Corrositex accurately predicted a noncorrosive end point for 1 (10%) of 10 formulations determined to be noncorrosive in animal studies. The Corrositex assay overpredicted the packing group for 12 (50%) of the 24 formulations, and under-predicted the packing group for 7 (29.2%) of the 24 formulations. Compared to the in vivo results, Corrositex correctly classified as corrosive or noncorrosive 37.5% of the formulations tested. A concordance of
Editeur
Sage
Identifiant
PMID : 12745991 ISSN : 1091-5818
Source
International journal of toxicology A. 2003, vol. 22, n° 2, pp. 99-107 [9 pages] [bibl. : 16 ref.]
Langue
Anglais
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