Détail de la notice
Titre du Document
Effect of sleep deprivation on insulin sensitivity and cortisol concentration in healthy subjects
Auteur(s)
GONZALEZ-ORTIZ M. ; MARTINEZ-ABUNDIS E. ; BALCAZAR-MUNOZ B. R. ; ...
Résumé
The objective of this study was to assess insulin sensitivity and cortisol concentration in healthy subjects with 24-hr sleep deprivation. A randomised, single-blind, controlled clinical trial was performed in 28 healthy subjects. Fourteen individuals were studied before and after 24-hr sleep deprivation and 14 volunteers with normal sleep periods (NSP) as a control group. Serum creatinine, uric acid, total cholesterol, high-density lipoprotein cholesterol, and triglyceride concentrations were measured in both groups. Insulin suppression test modified with octreotide (IST) and cortisol levels were performed before and after 24-hr sleep deprivation or NSP. Clinical and metabolic characteristics of the subjects in both groups are similar. Steady-state glucose (SSG) concentration of the IST was significantly higher after 24-hr sleep deprivation (5.7±2.1 vs 6.7±2.2 mmol/l; p=0.01). SSG level was similar before and after NSP (5.0±2.1 vs 5.0±1.8 mmol/l, respectively; p=0.91). There were not significant differences in cortisol levels between initial and final tests in both groups. In conclusion, 24-hr sleep deprivation decreased the insulin sensitivity in healthy subjects without changes in cortisol levels.
Editeur
Kurtis
Type du document
Conférence : International Symposium on Amino Acid/Protein Metabolism in Health and Disease: State of the art at the turn of the Millennium, 5, INC
Identifiant
PMID : 10898125 ISSN : 0394-3402
Source
Diabetes, nutrition & metabolism (Testo stampato) A. 2000, vol. 13, n° 2, pp. 80-83 [bibl. : 13 ref.]
Langue
Anglais
Pour les membres de la communauté du CNRS, ce document est autorisé à la reproduction à titre gratuit.
Pour les membres des communautés hors CNRS, la reproduction de ce document à titre onéreux sera fournie sous réserve d’autorisation du Centre Français d’exploitation du droit de Copie.

Pour bénéficier de nos services (strictement destinés aux membres de la communauté CNRS (Centre National de la Recherche Scientifique), de l'ESR français (Enseignement Supérieur et Recherche), et du secteur public français & étranger) :