Détail de la notice
Titre du Document
Alcohol consumption and risk of Type 2 diabetes mellitus among US male physicians
Auteur(s)
AJANI U. A. ; HENNEKENS C. H. ; SPELSBERG A. ; ...
Résumé
Objective: To examine the association between low to moderate alcohol consumption and the incidence of type 2 diabetes mellitus (DM) in men. Design: Prospective cohort study. Subjects and Methods: Over an average period of 12.1 years, we evaluated 20 951 participants in the Physicians' Health Study between ages 40 and 84 years who were free of cardiovascular disease, cancer, and diabetes and provided data on alcohol consumption at baseline. Main Outcome Measure: Type 2 DM diagnosed after randomization. Results: Among 20 951 physicians, 766 cases of incident DM were reported over an average follow-up period of 12.1 years. After adjustment for age, randomized treatment assignment, smoking, physical activity, and body mass index, the relative risk estimates and 95% confidence intervals for those reporting alcohol use of rarely/ never, 1 to 3 drinks per month, 1 drink per week, 2 to 4 drinks per week, 5 to 6 drinks per week, and 1 or more drinks per day were 1.00 (referent), 1.03 (0.80-1.33), 0.89 (0.70-1.14), 0.74 (0.59-0.93), 0.67 (0.51-0.89), and 0.57 (0.45-0.73), respectively (linear trend, P<.001). Additional adjustment for baseline history of hypertension, high cholesterol level, or parental history of myocardial infarction or family history of diabetes (data collected at 9 years) did not materially alter the results. These associations persisted in analyses stratified by age, smoking status, body mass index, physical activity, and family history of DM. Conclusion: These da
Editeur
American Medical Association
Identifiant
PMID : 10761969 ISSN : 0003-9926 CODEN : AIMDAP
Source
Archives of internal medicine (1960) A. 2000, vol. 160, n° 7, pp. 1025-1030 [bibl. : 34 ref.]
Langue
Anglais
Pour les membres de la communauté du CNRS, ce document est autorisé à la reproduction à titre gratuit.
Pour les membres des communautés hors CNRS, la reproduction de ce document à titre onéreux sera fournie sous réserve d’autorisation du Centre Français d’exploitation du droit de Copie.

Pour bénéficier de nos services (strictement destinés aux membres de la communauté CNRS (Centre National de la Recherche Scientifique), de l'ESR français (Enseignement Supérieur et Recherche), et du secteur public français & étranger) :