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Titre du Document
Urinary type IV collagen excretion reflects renal morphological alterations and type IV collagen expression in patients with type 2 diabetes mellitus
Auteur(s)
OKONOGI H. ; NISHIMURA M. ; UTSUNOMIYA Y. ; ...
Résumé
Aim: We tried to establish the significance of quantifying urinary type IV collagen (IV-C) excretion for the evaluation of renal involvement of type 2-diabetic patients. Methods: Twenty patients (13 males and 7 females; age range 31 to 69 years) with type 2 diabetes mellitus had undergone renal biopsy and relationship between the severity of morphological alteration, IV-C expression and urinary IV-C excretion were examined. Results: Urinary IV-C excretion significantly correlated with mesangial expansion score (p = 0.49, p <0.05) and tubulointerstitial injury score (p = 0.56, p < 0.05). Furthermore, urinary IV-C excretion significantly correlated with both glomerular (r = 0.56, p <0.01) and tubulointerstitial IV-C expression areas. Urinary protein excretion also correlated with mesangial expansion score and tubulointerstitial injury score. However, it did not correlate with the expression of IV-C in the kidney. Conclusions: These results suggest that urinary IV-C excretion reflects the pathogenetic process of diabetic nephropathy, which urinary protein excretion alone cannot do sufficiently. It can be concluded that urinary IV-C excretion could be a more useful marker for the evaluation of renal involvement of type 2-diabetic patients.
Editeur
Dustri
Identifiant
PMID : 11393380 ISSN : 0301-0430 CODEN : CLNHBI
Source
Clinical nephrology A. 2001, vol. 55, n° 5, pp. 357-364 [bibl. : 25 ref.]
Langue
Anglais
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