Détail de la notice
Titre du Document
Effects of estrogen, progesterone, and methoxychlor on surgically induced endometriosis in rats
Auteur(s)
CUMMINGS A. M. ; METCALF J. L.
Résumé
Endometriosis is a disease of women where endometrial tissue is found growing at ectopic sites. While evidence suggesting a role for the ovarian hormones in endometriosis exists, no complete studies of the roles of estrogen and progesterone have heretofore been performed. Also, if estrogen has a role in the growth and/or maintenance of endometriosis, it is likely that the proestrogenic pesticide, methoxychlor (MXC), might also have such an effect. Sixty rats underwent surgery on Day 0 to induce endometriosis. On Day 21, all rats were ovariectomized. During surgery, the diameters of all endometriotic implants (which were fully developed) were measured. Starting on Day 21, groups of rats were treated daily, for 3 weeks, with (a) vehicle ; (b) estrone, 1 μg/rat, E ; (c) progesterone, 2 mg/rat, P ; (d) E + P, 1 μg + 2 mg ; (e) MXC, 250 mg/kg ; or (f) MXC + P, 250 mg/kg + 2 mg/rat. On Day 42, all rats were killed, and the diameters of all endometriotic sites were measured. While no differences in diameter were found across groups prior to ovariectomy, ovariectomy plus treatment altered the growth of endometriotic tissue. Progesterone and vehicle treatments produced results that were identical : regression of endometriotic sites. Both estrogen and MXC treatments maintained endometriotic site size at a level greater than that in the vehicle-treated group. The combination of progesterone with either estrone or MXC did not alter the effect of either chemical. We conclude that while
Editeur
Academic Press; Academic Press; Academic Press
Identifiant
PMID : 8529825 ISSN : 0272-0590 CODEN : FAATDF
Source
Fundamental and applied toxicology (Print) A. 1995, vol. 27, n° 2, pp. 287-290 [bibl. : 20 ref.]
Langue
Anglais
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