Détail de la notice
Titre du Document
Prognosis of orbital lymphoid hyperplasia
Auteur(s)
POLITO E. ; LECCISOTTI A.
Résumé
Background : Orbital lymphoid hyperplasia can be associated with systemic non-Hodgkin lymphoma (NHL), even when polyclonal proliferation is found in the orbit. Although irradiation is recommended, some orbital lymphoid hyperplasias are treated by steroids (when inflammation is clinically presumed) or left untreated. . Methods : The incidence of concurrent NHL and the incidence of future NHL after oral prednisone, radiotherapy, or no treatment were retrospectively evaluated in 33 cases of lymphoid hyperplasia (22 benign lymphoid hyperplasias, BLH, and 11 atypical lymphoid hyperplasias, ALH), after follow-up of 2-13 years.. Results : NHL occurred in 12 of 33 cases (36.4%). In seven patients it was concurrent ; in five patients it occurred 2-6 years later. In the actuarial curve, at 5 years 55% of patients were free of lymphoma, at 10 years, 46%. NHL was more commonly observed when the lacrimal gland was involved (57% vs 21% ; P=0.03). Of the 13 patients treated with oral steroids, 46% had complete response, 39% partial response, and 15% future NHL. Of the seven irradiated patients, five (71%) had complete response, two (29%) partial response, and none future NHL. Of the eight untreated patients, five (63%) had partial response and three (37%) future NHL. Irradiated lacrimal gland BLHs only achieved partial response, one having radiation-induced orbital inflammation.. Conclusion : Because of a high risk of NHL, in all orbital lymphoid tumors systemic staging and follow-up are ma
Editeur
Springer
Identifiant
PMID : 8720713 ISSN : 0721-832X CODEN : GACODL
Source
Graefe's archive for clinical and experimental ophthalmology A. 1996, vol. 234, n° 3, pp. 150-154 [bibl. : 24 ref.]
Langue
Anglais
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