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Titre du Document
Royal jelly, a possible agent to reduce the nicotine-induced atherogenic lipoprotein profile
Auteur(s)
ABOU-HOZAIFA B. M. ; BADR EL-DIN N. K.
Résumé
Objective : The study investigated the effect of royal jelly on the nicotine-induced atherogenic lipoprotein profile. Design : To evaluate the changes in lipid and lipoprotein cholesterol concentrations, royal jelly (1 mg/g body weight/day) and/or nicotine (0.05 mg/ml in drinking water, a dose which simulated intake by heavy smokers) were tested in adult male rats, following 8 weeks of their oral supplementation. Results : Neither royal jelly nor nicotine or their combination significantly changed serum total cholesterol and triglyceride levels. Additionally royal jelly did not significantly change serum lipoprotein cholesterol concentrations. Oral nicotine alone progressively inhibited weight gain and significantly lowered the high density lipoprotein cholesterol level and its ratio to the total cholesterol (by 19% and 23% respectively). Also nicotine elevated the low density lipoprotein/high density lipoprotein (LDL/HDL) cholesterol ratio (82%) significantly. On the other hand, royal jelly when given to nicotine treated rats increased the HDL cholesterol and HDL/total cholesterol ratio and decreased the LDL/HDL cholesterol ratio to reach values insignificantly different from the control. Royal jelly also prevented the progressive decline in body weight gain caused by nicotine administration. Conclusion : Our data demonstrated that royal jelly is a potential antiatherosclerotic agent capable of improving the nicotine-induced atherogenic lipoprotein profile.
Editeur
Saudi Medical Journal
Identifiant
ISSN : 0379-5284 CODEN : SAMJDI
Source
Saudi medical journal A. 1995, vol. 16, n° 4, pp. 337-342 [bibl. : 40 ref.]
Langue
Anglais
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