Détail de la notice
Titre du Document
Effects of Glucosyl Hesperidin on Serum Triglyceride and its Safety in Beverage
Auteur(s)
TANAKA Yasushi ; IMATOMI Hiroko ; TAKIHARA Takanobu ; ...
Résumé
We evaluated the effect of glucosyl hesperidin-containing beverage on serum triglyceride level in the case of long-term ingestion and the safety in the case of excessive ingestion. As long-term ingestion trial, a randomized double-blind placebo-controlled study for 12 weeks was conducted. The test beverage (500 mL/bottle) contained 340 mg monoglucosyl hesperidin. The total 112 healthy adults with serum triglyceride level of 120-200 mg/ dL were divided into two groups: the test group and the placebo group. Each subject in the test group was given 1 bottle of the test drink per day (monoglucosyl hesperidin 340 mg/day) for 12 weeks. On the other hand, each subject in the placebo group was given 1 bottle of the placebo drink per day. 99 subjects (47 males and 52 females) had finished the trial. In the test group, serum triglyceride levels were reduced significantly at 4 weeks (p < 0.01), 8 weeks (p < 0.05) , 12 weeks (p<0.01) as compared with the placebo group. And no adverse effects were found in physiological, biochemical parameters and medical interviews throughout this trial. On excessive ingestion trial, the test beverage (500 mL/bottle) contained 1030 mg mono- glucosyl hesperidin. The total 44 healthy adults were given 1 bottle of the drink per day (monoglucosyl hesperidin 1030 mg/day) for 4 weeks. 34 subjects (17 males and 17 females) had finished the trial. No adverse effects were found in physiological, biochemical parameters and medical interviews throughout this trial.
Editeur
Life Science
Identifiant
ISSN : 0386-3603 CODEN : YACHDS
Source
Yakuri to chiryo A. 2010, vol. 38, n° 6, pp. 553-568 [16 pages]
Langue
Japonais
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