Détail de la notice
Titre du Document
Extract of the aerial parts of Aster koraiensis reduced development of diabetic nephropathy via anti-apoptosis of podocytes in streptozotocin-induced diabetic rats
Auteur(s)
SOHN Eunjin ; KIM Junghyun ; KIM Chan-Sik ; ...
Résumé
Advanced glycation end products (AGEs) is produced from glycolysis in vivo, which may result in diabetic nephropathy. Podocyte loss has been implicated in the development of diabetic nephropathy. The aim of this study was to investigate the protective effects ofAster koraiensis extract (AKE), on the damage of renal podocytes in streptozotocin (STZ)-induced diabetic rats. AKE (100, 200 mg/kg per day) was given to diabetic rats for 13 weeks. Blood glucose, glycated haemoglobin (HbA1c), proteinuria and albuminuria were examined. Kidney histopathology, AGEs accumulation, apoptosis, and expression of Bax and Bcl-2 also were examined. In 20-week-old STZ-induced diabetic rats, severe hyperglycemia was developed, and proteinuria and albuminuria were markedly increased. TUNEL-positive signals were highly detected in glomeruli of STZ-induced diabetic rats. However, AKE reduced proteinuria and albuminuria in diabetic rats. AKE prevented AGEs deposition and podocyte apoptosis. Expression of Bax and Bcl-2 protein were restored by AKE treatment in the renal cortex. These results suggested that AKE has an inhibitory effect of AGE accumulation and anti-apoptotic effect in the glomeruli of diabetic rat. AKE could be beneficial in preventing the progression of diabetic nephropathy.
Editeur
Elsevier
Identifiant
PMID : 19944074 ISSN : 0006-291X CODEN : BBRCA9
Source
Biochemical and biophysical research communications (Print) A. 2010, vol. 391, n° 1, pp. 733-738 [6 pages]
Langue
Anglais
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