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Titre du Document
Increased blood mercury levels in patients with Alzheimer's disease
Auteur(s)
HOCK C. ; DRASCH G. ; GOLOMBOWSKI S. ; ...
Résumé
Alzheimer's disease (AD) is a common neurodegenerative disorder that leads to dementia and death. In addition to several genetic parameters, various environmental factors may influence the risk of getting AD. In order to test whether blood levels of the heavy metal mercury are increased in AD. we measured blood mercury concentrations in AD patients (n = 33), and compared them to age-matched control paticnts with major depression (MD) (n = 45). as well as to an additional control group of patients with various non-psychiatric disorders (n = 65). Blood mercury levels were more than two-fold higher in AD patients as compared to both control groups (p = 0.0005, and p = 0.000, respectively). In early onset AD patients (n = 13). blood mercury levels were almost three-fold higher as compared to controls (p = 0.0002, and p = 0.0000, respectively). These increases were unrelated to the patients' dental status. Linear regression analysis of blood mercury concentrations and CSF levels of amyloid β-peptide (Aβ) revealed a significant correlation of these measures in AD patients (n = 15, r = 0.7440, p = 0.0015, Pearson type of correlation). These results demonstrate elevated blood levels of mercury in AD, and they suggest that this increase of mercury levels is associated with high CSF levels of Aβ, whereas tau levels were unrelated. Possible explanations of increased blood mercury levels in AD include yet unidentified environmental sources or release from brain tissue with the advance
Editeur
Springer; Springer
Identifiant
PMID : 9588761 ISSN : 0300-9564 CODEN : JNTMAH
Source
Journal of neural transmission A. 1998, vol. 105, n° 1, pp. 59-68 [bibl. : 1 p.1/4]
Langue
Anglais
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