Détail de la notice
Titre du Document
Systemic lgG4-related lymphadenopathy : a clinical and pathologic comparison to multicentric Castleman's disease
Auteur(s)
SATO Yasuharu ; KOJIMA Masaru ; TAKATA Katsuyoshi ; ...
Résumé
ΙgG4-related disease sometimes involves regional and/or systemic lymph nodes, and often clinically and/or histologically mimics multicentric Castleman's disease or malignant lymphoma. In this study, we examined clinical and pathologic findings of nine patients with systemic lgG4-related lymphadenopathy. None of these cases were associated with human herpes virus-8 or human immunodeficiency virus infection, and there was no T-cell receptor or immunoglobulin gene rearrangement. Histologically, systemic lgG4-related lymphadenopathy was classified into two types by the infiltration pattern of lgG4-positive cells: interfollicular plasmacytosis type and intra-germinal center plasmacytosis type. The interfollicular plasmacytosis type showed either Castleman's disease-like features or atypical lymphoplasmacytic and immunoblastic proliferation-like features. By contrast, the intra-germinal center plasmacytosis type showed marked follicular hyperplasia, and infiltration of lgG4-positive cells mainly into the germinal centers, and some cases exhibited features of progressively transformed germinal centers. Interestingly, eight of our nine (89%) cases showed eosinophil infiltration in the affected lymph nodes, and examined patients showed high elevation of serum IgE. Laboratory examinations revealed elevation of serum lgG4 and soluble interleukin-2 receptors. However, the levels of interleukin-6, C-reactive protein, and lactate dehydrogenase were within normal limits or only slightly el
Editeur
Nature Publishing
Identifiant
ISSN : 0893-3952
Source
Modern pathology A. 2009, vol. 22, n° 4, pp. 589-599 [11 pages]
Langue
Anglais
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