Détail de la notice
Titre du Document
Serum and salivary oxidative analysis in Complex Regional Pain Syndrome
Auteur(s)
EISENBERG Elon ; SHTAHL Shalom ; GELLER Rimma ; ...
Résumé
Although both inflammatory and neural mechanisms have been suggested as potential contributors to Complex Regional Pain Syndrome type I (CRPS-I), the pathogenesis of the syndrome is still unclear. Clinical trials have shown that free radical scavengers can reduce signs and symptoms of CRPS-I, indirectly suggesting that free radicals and increased oxidative stress are involved in the pathogenesis of CRPS-I. This study investigated this premise by determining the levels of antioxidants in the serum and saliva of 31 patients with CRPS-I and in a control group of 21 healthy volunteers. Serum lipid peroxidation products (MDA) and all antioxidative parameters analyzed were significantly elevated in CRPS-I patients: median salivary peroxidase and superoxide dismutase (SOD) activity values, uric acid (UA) concentration and total antioxidant status (TAS) values were higher in CRPS-I patients by 150% (p = 0.01), 280% (p = 0.04), 60% (P = 0.0001), and 200% (p = 0.0003), respectively, as compared with controls. Similar although not as extensive pattern of oxidative changes were found in the serum: mean serum UA and MDA concentrations and TAS value in the CRPS-I patients were higher by 16% (p - 0.04), 25% (p = 0.02), and 22% (p = 0.05), respectively, than in the controls. Additionally, median salivary albumin concentration and median salivary LDH activities in the patients were 2.5 times (p = 0.001) and 3.1 (p = 0.004) times higher than in the controls. The accumulated data show that free
Editeur
Elsevier
Identifiant
PMID : 18539395 ISSN : 0304-3959 CODEN : PAINDB
Source
Pain (Amsterdam) A. 2008, vol. 138, n° 1, pp. 226-232 [7 pages] [bibl. : 44 ref.]
Langue
Anglais
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