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Titre du Document
Vitamin D2 supplementation induces the development of aortic stenosis in rabbits : Interactions with endothelial function and thioredoxin-interacting protein
Auteur(s)
NGO Doan T. M. ; STAFFORD Irene ; KELLY Darren J. ; ...
Résumé
Understanding of the pathophysiology of aortic valve stenosis (AVS) and finding potentially effective treatments are impeded by the lack of suitable AVS animal models. A previous study demonstrated the development of AVS in rabbits with vitamin D2 and cholesterol supplementation without any hemodynamic changes in the cholesterol supplemented group alone. The current study aimed to determine whether AVS develops in an animal model with vitamin D2 supplementation alone, and to explore pathophysiological mechanisms underlying this process. The effects of 8 weeks' treatment with vitamin D2 alone (n=8) at 25,000 IU/4 days weekly on aortic valve structure and function were examined in male New Zealand white rabbits. Echocardiographic aortic valve backscatter (AVBS), transvalvular velocity, and transvalvular pressure gradient were utilized to quantitate changes in valve structure and function. Valvular histology/ immunochemistry and function were examined after 8 weeks. Changes in valves were compared with those in endothelial function and in valvular measurement of thioredoxin-interacting protein (TXNIP), a marker/mediator of reactive oxygen species-induced oxidative stress. Vitamin D2 treated rabbits developed AVS with increased AVBS (17.6±1.4 dB vs 6.7±0.8 dB, P<0.0001), increased transvalvular velocity and transvalvular pressure gradient (both P<0.01 via 2-way ANOVA) compared to the control group. There was associated valve calcification, lipid de
Editeur
Elsevier
Identifiant
ISSN : 0014-2999 CODEN : EJPHAZ
Source
European journal of pharmacology A. 2008, vol. 590, n° 1-3, pp. 290-296 [7 pages] [bibl. : 3/4 p.]
Langue
Anglais
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