Détail de la notice
Titre du Document
Royal Jelly Peptides Inhibit Lipid Peroxidation In Vitro and In Vivo
Auteur(s)
GUO Hang ; EKUSA Ai ; IWAI Koji ; ...
Résumé
Royal jelly peptides (RJPx) isolated from hydrolysates of water-soluble royal jelly proteins prepared with protease P exhibited significantly stronger hydroxyl radical-scavenging activity (p<0.001), and antioxidant activity against lipid peroxidation (LPO, p<0.001), than did water-soluble royal jelly protein (WSRJP) in vitro. We also investigated the in vivo antioxidant activity of RJPx against ferric nitrilotriacetate (Fe-NTA)-induced LPO. Male Wistar rats were divided into a control group (Group C), an Fe-NTA group (Group Fe), and an Fe-NTA with RJPx group (Group Fe+R). Rats in Group Fe+R were fed RJPx (2 g/ kg body weight) daily for 5 wk. Fe-NTA (8 mg Fe/kg body weight) was then intraperitoneally injected, and serum lipid levels were examined 2 h later. Serum total cholesterol (TC) levels were lower (p<0.05) while low-density lipoprotein (LDL) and LPO were significantly higher (p<0.01) in Group Fe than in Group C. TC (p<0.05) and LPO levels (p<0.01) were lower in Group Fe+R than in Group Fe. Our data suggest that RJPx may inhibit LPO both in vitro and in vivo.
Editeur
Center for Academic Publications Japan
Identifiant
ISSN : 0301-4800
Source
Journal of nutritional science and vitaminology A. 2008, vol. 54, n° 3, pp. 191-195 [5 pages] [bibl. : 41 ref.]
Langue
Anglais
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