Détail de la notice
Titre du Document
GabaB receptors activation in the NTS blocks the glycemic responses induced by carotid body receptor stimulation
Auteur(s)
LEMUS Monica ; MONTERO Sergio ; CADENAS José Luis ; ...
Résumé
The carotid body receptors participate in glucose regulation sensing glucose levels in blood entering the cephalic circulation. The carotid body receptors information, is initially processed within the nucleus tractus solitarius (NTS) and elicits changes in circulating glucose and brain glucose uptake. Previous work has shown that γ-aminobutyric acid (GABA) in NTS modulates respiratory reflexes, but the role of GABA within NTS in glucose regulation remains unknown. Here we show that GABAB receptor agonist (baclofen) or antagonists (phaclofen and CGP55845A) locally injected into NTS modified arterial glucose levels and brain glucose retention. Control injections outside NTS did not elicit these responses. In contrast, GABAA agonist and antagonist (muscimol or bicuculline) produced no significant changes in blood glucose levels. When these GABAergic drugs were applied before carotid body receptors stimulation, again, only GABAB agonist or antagonist significantly affected glycemic responses; baclofen microinjection significantly reduced the hyperglycemic response and brain glucose retention observed after carotid body receptors stimulation, while phaclofen produced the opposite effect, increasing significantly hyperglycemia and brain glucose retention. These results indicate that activation of GABAB, but not GABAA, receptors in the NTS modulates the glycemic responses after anoxic stimulation of the carotid body receptors, and suggest the presence
Editeur
Elsevier
Identifiant
PMID : 18599364 ISSN : 1566-0702
Source
Autonomic neuroscience : basic & clinical A. 2008, vol. 141, n° 1-2, pp. 73-82 [10 pages] [bibl. : 1 p.1/4]
Langue
Anglais
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