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Treatment Against Blood-Sucking Insects Without Skin Irritation
In recent times the increasing incidence of head lice infestations (Pediculus humanus capitis) has resulted in a significant impact on social relationships in children's playgrounds and schoolyards and has affected family activities. Many anti-louse shampoos show reduced activity or irritate the skin. They were ineffective or used in low concentrations due to the painful sensations. A newly developed anti-louse shampoo (Wash-Away®) with neem seed extract (Melia azadirachta, 10%) as active ingredient was proved in volunteer studies to be effective and skin compatible. In this in-vitro BUS-study (modified rinse-off conditions, undiluted open application, MTT-assay, Prostaglandin E2 (PGE2) - tissue concentration) the skin compatibility of Wash-Away® was compared with a well known brand (Nivea Silky Shine®), Wash-Away® formulation without active ingredient, the pure neem seed extract and the solvent DBE-2. The skin compatibility of both market products, Nivea Silky Shine®, Wash-Away® were excellent and quite comparable. No statistically significant differences (MTT/ PGE2) between the two shampoos at any exposure period (0,5h, 1,0h, 5,0h)could be obtained. The active ingredient neem seed extract does not substantially alter the biological properties of the shampoo formulation regarding skin compatibility. The application of pure neem seed extract and the solvent DBE-2 provokes a low skin compatibility. Additionally the application of DBE-2 increased signifi
Verlag für chemische Industrie
ISSN : 0942-7694
SÖFW-journal A. 2008, vol. 134, n° 5, [36-43 [7 p.]] [bibl. : 17 ref.]
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