Détail de la notice
Titre du Document
Pre-Exposure Rabies Vaccination Using Purified Chick Embryo Cell Rabies Vaccine Intradermally is Immunogenic and Safe
Auteur(s)
KAMOLTHAM Thavatchai ; THINYOUNYONG Wirawan ; PHONGCHAMNAPHAI Phana ; ...
Résumé
Objective To demonstrate the safety and immunogenicity of intradermal rabies pre-exposure prophylaxis with purified chick embryo cell vaccine (PCECV) in schoolchildren age 5 to 8 years in Thailand. Study design In a randomized, open-label, phase II clinical trial, 2 or 3 intradermal doses of 0.1 mL PCECV (Rabipur®) were administered to 703 schoolchildren on days 0 and 28 or on days 0, 7, and 28. In 206 children, 2 simulated post-exposure booster doses were given 1 year after the primary vaccination series. Rabies virus- neutralizing antibody (RVNA) titers were determined by the rapid fluorescent focus inhibition test. Results In school-age children in Thailand, a pre-exposure immunization regimen of 3 intradermal doses of PCECV produced adequate immune responses. After primary vaccination, all subjects developed RVNA titers ≥0.5 lU/mL and demonstrated a rapid increase in RVNA titer after 2 simulated post-exposure booster immunizations 1 year after the primary vaccination series. No serious adverse drug reactions occurred. Conclusions Rabies pre-exposure immunization with PCECV is safe and immunogenic, and its implementation could save the lives of many children in rabies-endemic areas.
Editeur
Elsevier
Identifiant
ISSN : 0022-3476 CODEN : JOPDAB
Source
The Journal of pediatrics A. 2007, vol. 151, n° 2, pp. 173-177 [5 pages] [bibl. : 21 ref.]
Langue
Anglais
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