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Titre du Document
Adrenocorticotropic hormone/cortisol response to physical exercise in abstinent alcoholic patients
Auteur(s)
COIRO Vittorio ; CASTI Amos ; JOTTI Gloria Saccani ; ...
Résumé
Background: Alterations in the hypothalamic-pituitary-adrenal (HPA) axis in alcoholic patients have been reported in various experimental conditions. Methods: To establish whether alcoholism affects the HPA axis activation during physical exercise, 10 recent abstinent alcoholic patients (age range: 33-45 years; duration of alcohol dependence: range 4-6 years) were tested by exercising on a bicycle ergometer. Ten age-matched healthy nonalcoholic men participated as controls. The workload was gradually increased at 3-minute intervals until exhaustion and lasted about 15 minutes for all subjects. Alcoholic patients were tested at 3 time points, at 4, 6, and 8 weeks after alcohol withdrawal, whereas controls were tested only once.Main outcome measurements were circulating levels of adrenocorticotropic hormone (ACTH) and cortisol and physiological variables during physical exercise [heart rate, blood pressure, ventilation, frequency of breathing, tidal volume, oxygen consumption (VO2), carbon oxide production (VCO2), and respiratory exchange ratio (R)]. Results: Similar basal and exercise-induced changes in physiological variables were observed in controls and alcoholic patients in all tests.Basal levels of ACTH and cortisol were similar in all tests performed on alcoholic patients and on normal controls. In normal subjects, exercise induced a significant increase in plasma ACTH and serum cortisol levels, with peak levels at 20 minutes for ACTH (84% higher than baselin
Editeur
Lippincott Williams & Wilkins
Identifiant
ISSN : 0145-6008 CODEN : ACRSDM
Source
Alcoholism, clinical and experimental research A. 2007, vol. 31, n° 5, pp. 901-906 [6 pages] [bibl. : 3/4 p.]
Langue
Anglais
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