Détail de la notice
Titre du Document
Eosinophil cationic protein (ECP) polymorphisms and association with asthma, s-ECP levels and related phenotypes
Auteur(s)
MUNTHE-KAAS M. C. ; GERRITSEN J. ; CARLSEN K. H. ; ...
Résumé
Background: Eosinophil cationic protein (ECP) is a potent cytotoxic secretory protein with bactericidal and antiviral properties. ECP is released by activated eosinophils and regarded as a marker of eosinophilic inflammation. High levels of ECP have been reported in cases of active asthma and other allergic diseases. This study aimed to assess whether three single-nucleotide polymorphisms (SNPs) in the ECP gene (RNASE3) on chromosome 14 q24-q31 or their haplotypes are associated with asthma, allergy, or related phenotypes. Methods: The three SNPs -38CA, + 371CG and + 499CG in RNASE3 and their haplotypes were analyzed for associations with asthma, serum-ECP (s-ECP) levels, allergic sensitization (positive skin-prick test to common allergens), bronchial hyperresponsiveness (BHR) assessed by methacholine inhalation, and serum-IgE (s-IgE) levels in 177 families from Norway and the Netherlands identified through siblings with asthma. Results: Transmission disequilibrium test (TDT) demonstrated significant associations between the A-G-G haplotype and asthma as well as the specific phenotypes allergic asthma (but not non-allergic asthma), high s-ECP, high s-IgE and BHR, while the C-G-G haplotype was associated with reduced occurrence of these traits. In addition, the -38A allele was associated with high s-ECP levels and allergic asthma. Conclusion: The present study suggests that the A-G-G haplotype in the RNASE3 gene influences the development of asthma, in particular, an allergic
Editeur
Blackwell
Identifiant
PMID : 17362255 ISSN : 0105-4538 CODEN : LLRGDY
Source
Allergy (Copenhagen) A. 2007, vol. 62, n° 4, pp. 429-436 [8 pages] [bibl. : 34 ref.]
Langue
Anglais
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