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Titre du Document
Biological activity of isoquinoline alkaloids
Biochemistry
Auteur(s)
CAPASSO Anna ; Pandalai S. G. (Editeur scientifique)
Résumé
Our interest has been centered on isoquinoline alkaloids (biologically derived from phenylalanine) from Argemone mexicana (Papaveraceae), Aristolochia constricta (Aristolochiaceae) and the opium alkaloid, papaverine. In this respect, the effect of isoquinoline alkaloids from A. mexicana and A. constricta was investigated on the naloxone-precipitated withdrawal contracture of the acute morphine-dependent guinea-pig ileum in vitro. Their activity was compared to the control compound, papaverine. Furthermore, the effect of these isoquinoline alkaloids was also considered on DAGO (highly selective μ-agonist) and U50-488H (highly selective k-agonist) withdrawal to test whether the possible interaction of isoquinoline alkaloids on opioid withdrawal involves μ-and/or k-opioid receptors. Isoquinoline alkaloids from A. mexicana (from 5×10-6 to 1×10-4 M), from A. constricta (1×10-5-5×10-5-1×10-4 M) as well as papaverine treatment (1×10-7-5×10-7-1×10-6 M) before or after the opioid agonists were able of both preventing and reversing the naloxone-induced contracture after exposure to μ (morphine and DAGO) or k (U50-488H) opiate agonists in a concentration-dependent manner. Both acetylcholine response and electrical stimulation were not affected by isoquinoline alkaloids and papaverine treatment whereas the final opiate withdrawal was still reduced. The results of the present study indicate that isoquinoline alkaloids as well as p
Editeur
Research signpost
Identifiant
ISSN : ISBN : 81-7736-297-6
Source
A. 2005, pp. 1-12 [12 pages] [bibl. : 39 ref.]
Langue
Anglais
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