Détail de la notice
Titre du Document
Effectiveness and cost-effectiveness of strategies to expand antiretroviral therapy in St. Petersburg, Russia
Auteur(s)
LONG Elisa F. ; BRANDEAU Margaret L. ; GALVIN Cristina M. ; ...
Résumé
Objective: To assess the effectiveness and cost-effectiveness of treating HIV-infected injection drug users (IDUs) and non-IDUs in Russia with highly active antiretroviral therapy HAART. Design and methods: A dynamic HIV epidemic model was developed for a population of IDUs and non-IDUs. The location for the study was St. Petersburg, Russia. The adult population aged 15 to 49 years was subdivided on the basis of injection drug use and HIV status. HIV treatment targeted to IDUs and non-IDUs, and untargeted treatment interventions were considered. Health care costs and quality-adjusted life years (QALYs) experienced in the population were measured, and HIV prevalence, HIV infections averted, and incremental cost-effectiveness ratios of different HAART strategies were calculated. Results: With no incremental HAART programs, HIV prevalence reached 64% among IDUs and 1.7% among non-IDUs after 20 years. If treatment were targeted to IDUs, over 400 00 infections would be prevented (75% among non-IDUs), adding 650 000 QALYs at a cost of US$1501 per QALY gained. If treatment were targeted to non-IDUs, fewer than 10000 infections would be prevented, adding 400000 QALYs at a cost of US$2572 per QALY gained. Untargeted strategies prevented the most infections, adding 950000 QALYs at a cost of US$1827 per QALY gained. Our results were sensitive to HIV transmission parameters. Conclusions: Expanded use of antiretroviral therapy in St. Petersburg, Russia would generate enormous population-w
Editeur
Lippincott Williams & Wilkins
Identifiant
PMID : 17086061 ISSN : 0269-9370
Source
AIDS (London) A. 2006, vol. 20, n° 17, pp. 2207-2215 [9 pages] [bibl. : 40 ref.]
Langue
Anglais
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