Détail de la notice
Titre du Document
Altered skin-temperature regulation in narcolepsy relates to sleep propensity
FRONCZEK Rolf ; OVEREEM Sebastiaan ; LAMMERS Gert Jan ; ...
Study Objectives: In healthy subjects, sleep propensity increases when the distal skin temperature increases relative to the proximal skin temperature. This increase results from increased blood flow in the skin of the extremities and is, among other factors, controlled by the hypothalamic circadian clock, as is sleep. Because narcolepsy is characterized by hypothalamic alterations, we studied skin temperature in narcoleptic patients in relation to their characteristically increased sleep propensity during the day. Design: Distal and proximal skin temperature and their gradient (DPG) were measured during a Multiple Sleep Latency Test. This allowed temperature to be studied during wakefulness, at sleep onset and during sleep. Setting: Tertiary narcolepsy referral center in a university hospital. Patients: Fifteen unmedicated narcolepsy patients with cataplexy and 15 controls. Interventions: None. Measurements and Results: In subjects in the waking state, DPG was higher in narcoleptics than in controls throughout the day (time by group interaction, p <.0001), due to increased distal skin temperature and decreased proximal skin temperature. The increase in DPG was related to a shorter subsequent sleep-onset latency (p =.02). Once asleep, narcoleptics maintained their elevated distal skin temperature and DPG (p <.0001), whereas proximal skin temperature increased to reach normal levels. Conclusions: This is the first demonstration of a dramatic alteration of daytime skin temperat
American Academy of Sleep Medicine
PMID : 17162991 ISSN : 0161-8105 CODEN : SLEED6
Sleep (New York, NY) A. 2006, vol. 29, n° 11, pp. 1444-1449 [6 pages] [bibl. : 39 ref.]
Pour les membres de la communauté du CNRS, ce document est autorisé à la reproduction à titre gratuit.
Pour les membres des communautés hors CNRS, la reproduction de ce document à titre onéreux sera fournie sous réserve d’autorisation du Centre Français d’exploitation du droit de Copie.

Pour bénéficier de nos services (strictement destinés aux membres de la communauté CNRS (Centre National de la Recherche Scientifique), de l'ESR français (Enseignement Supérieur et Recherche), et du secteur public français & étranger) :