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Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women : a randomized controlled trial
Objective: To determine the safety and efficacy of a dietary supplement with a low dose of ephedra and caffeine in overweight/ obese premenopausal female subjects. Design: A 9-month, double-blind, randomized control study compared the efficacy and safety of a dietary supplement with ephedra and caffeine to a control supplement. Subjects: Sixty-one healthy, premenopausal women with body mass index (BMI) from 27 to 39 kg/m2 were randomly assigned and received a dietary supplement (40mg/day ephedra alkaloids, 100 mg/day caffeine, high potency mixture of vitamins, minerals, omega-3 fatty acids) or a control supplement for 9 months. Measurements: Efficacy: changes in body weight, body composition, lipids, insulin, leptin, adiponectin, ghrelin, and self-reports of physical activity, diet and quality of life indices. Safety: blood pressure, heart rate, electrocardiograms, urinalysis, blood histology, serum chemistry measures and self-reported symptoms. Results: Forty-one women completed the study. The treatment group lost significantly more body weight (-7.18 kg) and body fat (-5.33 kg) than the control group (-2.25 and -0.99 kg, respectively), and showed significant declines in heart rate, serum cholesterol, triglycerides, cholesterol to high-density lipoprotein ratio, glucose, fasting insulin, and leptin. Blood pressure, electrocardiograms, other clinical chemistry measures, blood histology, urinalysis, and self-reported physical activity were similar in the groups. Minor sy
Nature Publishing
PMID : 16552410 ISSN : 0307-0565 CODEN : IJOBDP
International journal of obesity A. 2006, vol. 30, n° 10, pp. 1545-1556 [12 pages] [bibl. : 47 ref.]
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