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Titre du Document
Meta-analysis: Cysticidal drugs for neurocysticercosis : Albendazole and praziquantel
Auteur(s)
DEL BRUTTO Oscar H. ; ROOS Karen L. ; COFFEY Christopher S. ; ...
Résumé
Background: Conflicting reports have caused controversy on whether cysticidal drugs modify the natural course of neurocysticercosis. Purpose: To perform a meta-analysis of randomized trials assessing the effect of cysticidal drugs on neuroimaging and clinical outcomes of patients with neurocysticercosis. Data Sources: Search of MEDLINE, Cochrane Database of Systematic Reviews, and Literatura Latino-Americana y del Caribe en Ciencias de la Salud (LILACS) between 1979 and 2005. There were no language restrictions. Study Selection: Randomized trials of cysticidal drug therapy for neurocysticercosis that met predefined criteria designed to allow characterization of the disease and objective evaluation of therapy. Data Abstraction: The authors independently reviewed articles. ed data included study design, number of randomly assigned patients and withdrawals, intervention, adverse events, timing of neuroimaging studies, and outcomes. Data Synthesis: Eleven studies met the inclusion criteria. Six trials randomly assigned 464 patients with cystic lesions (vesicular cysticerci), and 5 trials randomly assigned 478 patients with enhancing lesions (colloidal cysticerci). Parasites were located in the brain parenchyma or subarachnoid space at the convexity of the cerebral hemispheres. Cysticidal drug therapy was associated with complete resolution of cystic lesions (44% vs. 19%; P= 0.025). Trials on enhancing lesions showed a trend toward lesion resolution favoring the use of cysticidal
Editeur
American College of Physicians
Identifiant
PMID : 16818928 ISSN : 0003-4819 CODEN : AIMEAS
Source
Annals of internal medicine A. 2006, vol. 145, n° 1, pp. 43-51 [9 pages] [bibl. : 53 ref.]
Langue
Anglais
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