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Titre du Document
Butyrate, a small pleiotropic molecule with multiple cellular and molecular actions : Its role as an anti-atherogenic agent
Auteur(s)
RANGANNA Kasturi ; YATSU Frank M. ; HAYES Barbara E. ; ...
Résumé
Evidence from various epidemiological and interventional studies has increased our awareness of the importance of diet and nutrition in human health and disease. Among the dietary habits, intake of high fiber diets has been linked to protection against chronic diseases such as cardiovascular disease, cancer, diabetes, obesity and neurological disorders, particularly atherosclerotic vascular disease and colorectal cancer. Butyrate, a natural bacterial fermentation product of dietary fiber produced in the mammalian colon, appears to mediate the protective role of a high fiber diet. In vitro studies have revealed that butyrate elicits many cytoprotective responses, which include stimulation of cell differentiation, arrest of cell proliferation, enhancement of the anti-inflammatory response, induction ofapoptosis, up-regulation of the anti-oxidant system, and down-regulation ofangiogenesis. However, it is not clear how this simple four-carbon molecule achieves these multiple effects to prevent colorectal cancer and offer protection against atherosclerotic vascular diseases and other chronic diseases. Recent advances in chromatin biology indicate that butyrate stimulates chromatin remodeling through its action as an inhibitor of histone deacetylase. Although extensive evidence supporting butyrate as an anti-cancer agent is available, few studies have investigated the role of butyrate as an anti-atherogenic agent whereby butyrate inhibits vascular smooth muscle cell proliferation,
Editeur
Research signpost
Identifiant
ISSN : ISBN : 81-7736-294-1
Source
A. 2005, pp. 123-151 [29 pages] [bibl. : 118 ref.]
Langue
Anglais
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