Détail de la notice
Titre du Document
Clinical studies on the anti-irritation effects of mung bean (Phaseolus aureus) extract in cosmetics
Auteur(s)
JO B.-K. ; AHN G.-W. ; JEONG J.-H. ; ...
Résumé
The aim of this study is to assess the anti-irritation activities of mung bean (Phaseolus aureus) extract against various irritants used in cosmetics. For its antidotal activity, mung bean has been used as a medicinal or cosmetic material since ancient times. However, there have been few reports describing the biological activities of these beans and no comprehensive surveys of the constituents. An ethanolic extract of mung bean was obtained and the major constituents, such as vitexin and isovitexin, were isolated. It was previously reported that the mung bean extract containing vitexin and isovitexin had excellent antioxidant and anti-inflammatory activities. To investigate the mechanisms of anti-inflammatory activity of mung bean extract, the inhibitory effects on histamine release from rat peritoneal mast cells and lipoxygenase activity were examined. Mung bean extract inhibited histamine release in a concentration dependent manner but showed no inhibitory activity in the 5-lipoxygenase assay. And, clinical studies were conducted to evaluate the anti-irritation effects of mung bean extract against various irritants used in cosmetics such as lactic acid, retinol, and preservatives. When 2.0% of mung bean extract was applied to cosmetic formulae containing each of irritants, it revealed considerable anti-irritation efficacy. Results of a human patch test with 20 volunteers showed that this extract reduced skin irritations caused by 5.0% lactic acid, 4000 ID retinol, and 1.0%
Editeur
Verlag für chemische Industrie
Identifiant
ISSN : 0942-7694
Source
SÖFW-journal A. 2006, vol. 132, n° 1-2, [8-16 [7 p.]] [bibl. : 16 ref.]
Langue
Anglais
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