Détail de la notice
Titre du Document
Recent progress in plantibody technology : Plants as sources of therapeutic proteins
Auteur(s)
STAGER E. ; SACK M. ; NICHOLSON L. ; ...
Résumé
Antibodies are an important class of proteins that can be used for the prevention, treatment and diagnosis of many diseases. Consequently, there is an intense and growing demand for recombinant antibodies, placing immense pressure on current production capacity which is based largely on microbial cultures and mammalian cells. Alternative systems for cost effective antibody production would be very welcome, and plants are now gaining widespread acceptance as green bioreactors with advantages in terms of cost, scalability and safety. Several plant-produced antibodies (plantibodies) are undergoing clinical trials and the first commercial approval could be only a few years away. The performance of the first generation of products has been very encouraging so far. In terms of product authenticity, differences in glycosylation between plantibodies and their mammalian counterparts have been defined, and the scientific evaluation of any possible consequences is underway. Ongoing studies are addressing the remaining biochemical constraints, and aim to further improve product yields, homogeneity and authenticity, particularly where the antibody is intended for injection into human patients. A remaining practical challenge is the implementation of large-scale production and processing under good manufacturing practice conditions that are yet to be endorsed by regulatory bodies. The current regulatory uncertainty and the associated costs represent an entry barrier for the pharmaceutical
Editeur
Bentham Science
Identifiant
PMID : 16026298 ISSN : 1381-6128
Source
Current pharmaceutical design A. 2005, vol. 11, n° 19, pp. 2439-2457 [19 pages] [bibl. : 148 ref.]
Langue
Anglais
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