Détail de la notice
Titre du Document
Acute blood glucose level and outcome from ischemic stroke
Auteur(s)
BRUNO A. ; BILLER J. ; ADAMS H. P. ; ...
Corporation(s) du ou des auteurs
Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Investigators INC
Résumé
Objective: To study the relation between acute blood glucose level and outcome from ischemic stroke. Background: Hyperglycemia may augment acute ischemic brain injury and increase the risk of hemorrhagic transformation of the infarct. Methods: The authors analyzed the relation between admission blood glucose level (within 24 hours from ischemic stroke onset) and clinical outcome in 1,259 patients enrolled in the Trial of ORG 10172 in Acute Stroke Treatment (TOAST)-a placebo-controlled, randomized, double-blind trial to test the efficacy of a low-molecular weight heparinoid in acute ischemic stroke. Very favorable outcome was defined as a Glasgow Outcome Scale score of 1 and a modified Barthel index of 19 or 20. Neurologic improvement at 3 months was defined as a decrease by ≥4 points on the NIH Stroke Scale compared with baseline or a final score of 0. Hemorrhagic transformation of infarct was assessed within 10 days after onset of stroke with repeat cerebral CT. Stroke subtype as lacunar or nonlacunar (atherothromboembolic, cardioembolic, and other or undetermined etiology) was classified by one investigator after completion of stroke evaluation according to study protocol. Results: In all strokes combined (p = 0.03) and in nonlacunar strokes (p = 0.02), higher admission blood glucose levels were associated with worse outcome at 3 months according to multivariate logistic regression analysis adjusted for stroke severity, diabetes mellitus, and other vascular risks. In lacu
Editeur
Lippincott Williams & Wilkins
Identifiant
PMID : 9932944 ISSN : 0028-3878 CODEN : NEURAI
Source
Neurology A. 1999, vol. 52, n° 2, pp. 280-284 [bibl. : 39 ref.]
Langue
Anglais
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