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Titre du Document
Intensive lifestyle changes for reversal of coronary heart disease
Auteur(s)
ORNISH D. ; SCHERWITZ L. W. ; BILLINGS J. H. ; ...
Résumé
Context.-The Lifestyle Heart Trial demonstrated that intensive lifestyle changes may lead to regression of coronary atherosclerosis after 1 year. Objectives.-To determine the feasibility of patients to sustain intensive lifestyle changes for a total of 5 years and the effects of these lifestyle changes (without lipid-lowering drugs) on coronary heart disease. Design.-Randomized controlled trial conducted from 1986 to 1992 using a randomized invitational design. Patients.-Forty-eight patients with moderate to severe coronary heart disease were randomized to an intensive lifestyle change group or to a usual-care control group, and 35 completed the 5-year follow-up quantitative coronary arteriography. Setting.-Two tertiary care university medical centers. Intervention.-lntensive lifestyle changes (10% fat whole foods vegetarian diet, aerobic exercise, stress management training, smoking cessation, group psychosocial support) for 5 years. Main Outcome Measures.-Adherence to intensive lifestyle changes, changes in coronary artery percent diameter stenosis, and cardiac events. Results.-Experimental group patients (20 [71%] of 28 patients completed 5-year follow-up) made and maintained comprehensive lifestyle changes for 5 years, whereas control group patients (15 [75%] of 20 patients completed 5-year follow-up) made more moderate changes. In the experimental group, the average percent diameter stenosis at baseline decreased 1.75 absolute percentage points after 1 year (a 4.5% relat
Editeur
American Medical Association
Identifiant
PMID : 9863851 ISSN : 0098-7484
Source
JAMA, the journal of the American Medical Association A. 1998, vol. 280, n° 23, pp. 2001-2007 [bibl. : 32 ref.]
Langue
Anglais
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