Détail de la notice
Titre du Document
Addition of the α2-antagonist yohimbine to fluoxetine: Effects on rate of antidepressant response
Auteur(s)
SANACORA Gerard ; BERMAN Robert M. ; CAPPIELLO Angela ; ...
Résumé
Electrophysiological studies suggest that α2-adrenoceptors profoundly affect monoaminergic neurotransmission by enhancing noradrenergic tone and serotonergic firing rates. Recent reports suggest that α2-antagonism may hasten and improve the response to antidepressant medications. To test this hypothesis, a randomized double-blind controlled trial was undertaken to determine if the combination of an α2-antagonist (yohimbine) with a selective serotonin reuptake agent (SSRI) (fluoxetine) results in more rapid onset of antidepressant action than an SSRI agent alone. In all, 50 subjects with a DSM-IV diagnosis of major depressive disorder confirmed by SCID interview were randomly assigned to receive either fluoxetine 20 mg plus placebo (F/P) or fluxetine 20 mg plus a titrated dose of yohimbine (F/Y). The yohimbine dose was titrated based on blood pressure changes over the treatment period, in a blind-preserving manner. Hamilton depression scale ratings (HDRS) and clinical global impression (CGI) ratings were obtained weekly over a period of 6 weeks. The rate of achieving categorical positive responses was significantly more rapid in the F/Y group compared to the F/P group using both the HDRS and the CGI scales as outcome measures in a survival analysis using a log-rank test (X2(I)=5.86, p=0.016 and X2(1)=5.29, p=0.021, respectively). At the last observed visit, 18 (69%) of the 26 F/Y subjects met the response criteria for CGI compared to 10 (42%) of 24 F/P subjects.
Editeur
Nature Publishing
Identifiant
PMID : 15010697 ISSN : 0893-133X CODEN : NEROEW
Source
Neuropsychopharmacology (New York, NY) A. 2004, vol. 29, n° 6, pp. 1166-1171 [6 pages] [bibl. : 28 ref.]
Langue
Anglais
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