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Titre du Document
Cukrzyca typu 2 : Epidemiologia, patogeneza, objawy i powiklania
Type 2 diabetes mellitus: epidemiology, pathogenesis, symptoms and complications
Diabetes mellitus is a metabolic disease characterized by hyperglycemia that results from defects in insulin secretion, insulin action, or both. Important abnormalities in fat and protein metabolism are also present. The classification of diabetes mellitus has recently been revised by a task force of the American Diabetes Association. A variety of pathogenic processes are involved in the development of different forms of diabetes. The basis for the metabolic abnormalities of type 2 diabetes mellitus is deficient action of insulin on its major target tissues, including skeletal muscle, adipose tissue, and liver. Loss of proper insulin regulation of metabolism results from inadequate secretion of insulin, from diminished tissue responses to insulin at one or more points in the complex pathways of insulin action, or from both processes. Impairment of insulin secretion and defects in insulin action coexist in many patients, and in these patients, it is often unclear which abnormality is the primary cause of the hyperglycemia. Most patients with type 2 disease have relatively mild polyuria and polydipsia, and many cases are diagnosed only by office screening or other health checks. The chronic hyperglycemia of diabetes mellitus is specifically associated with long-term damage, dysfunction, and failure of various organs, especially the retina of the eye, the kidneys, and both somatic and autonomic nervous systems. The heart, arterial system, and microcirculation are also adversely
Polish Pharmaceutical Society
ISSN : 0014-8261
Farmacja Polska A. 2003, vol. 59, n° 23, pp. 1055-1060 [6 pages]
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