Détail de la notice
Titre du Document
Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on Epstein-Barr virus activation
Auteur(s)
IWATSUKI Kenji ; AKIHISA Toshihiro ; TOKUDA Harukuni ; ...
Résumé
A new triterpene acid, lucidenic acid P (la), and two new triterpene acid methyl esters, methyl lucidenates P (1b) and Q (2b), were isolated and characterized from the fruiting body of the fungus Ganoderma lucidum. Their structures were elucidated on the basis of spectroscopic methods. In addition, eight known triterpene acids, lucidenic acids A (3a), C (4a), D2 (5a), E2 (6a), and F (7a) and ganoderic acids E (9a), F (lOa), and T-Q (lla), and six known triterpene acid methyl esters, methyl lucidenates A (3b), D2 (5b), E2 (6b), F (7b), and L (8b) and methyl ganoderate F (lOb), were isolated and identified from the fungus. All of the triterpenoids, with the exception of 7a, were evaluated with respect to their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, which is known to be a primary screening test for antitumor promoters. All of the compounds tested showed potent inhibitory effects on EBV-EA induction (96-100% inhibition at 1 x 103 mol ratio/TPA).
Editeur
American Chemical Society; American Society of Pharmacognosy
Identifiant
PMID : 14695801 ISSN : 0163-3864 CODEN : JNPRDF
Source
Journal of natural products (Print) A. 2003, vol. 66, n° 12, pp. 1582-1585 [4 pages]
Langue
Anglais
Pour les membres de la communauté du CNRS, ce document est autorisé à la reproduction à titre gratuit.
Pour les membres des communautés hors CNRS, la reproduction de ce document à titre onéreux sera fournie sous réserve d’autorisation du Centre Français d’exploitation du droit de Copie.

Pour bénéficier de nos services (strictement destinés aux membres de la communauté CNRS (Centre National de la Recherche Scientifique), de l'ESR français (Enseignement Supérieur et Recherche), et du secteur public français & étranger) :