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Theiler's murine encephalomyelitis virus (TMEV) : Molecular aspects of its persistence
OHARA Y. ; OBUCHI M. ; Pandalai S. G.
Theiler's murine encephalomyelitis virus (TMEV) belongs to the genus Cardiovirus of the family Picornaviridae and is divided into two subgroups strains on the basis of their different biological activities. GDVII subgroup strains are highly virulent and produce acute fatal polioencephalomyelitis in mice. In the few surviving mice, neither viral persistence nor demyelination occurs. On the other hand, DA (or TO) subgroup strains are less virulent and cause a biphasic disease; although these strains produce milder polioencephalomyelitis in the acute stage of infection, mice recover and show primary demyelination one month or later after the infection. DA strain persists in the spinal cords of mice despite a vigorous humoral immune response. TMEV is thought to be an excellent animal model for the human demyelinating disease, multiple sclerosis. There are several interesting features regarding TMEV persistence. 1) A majority of TMEV-infected cells during the chronic stage of disease contain a relatively small number of copies of the genome (100-500 copies) which is insufficient for the induction of detectable expression of viral proteins. The limited viral protein synthesis is predicted to induce relatively little cytopathic effect, and therefore to allow the virus to bypass immunological clearance. 2) Sequence analysis of escape mutant viruses resistant to DA neutralizing monoclonal antibodies has identified four separate sites for amino acid mutations of capsid proteins that le
Transworld research network
ISSN : ISBN : 81-86846-73-5
Recent research developments in virology A. 1999, pp. 897-918 [bibl. : 58 ref.]
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