Détail de la notice
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Titre du Document
Genistein as an anti-inflammatory agent
Auteur(s)
VERDRENGH M. ; JONSSON I. M. ; HOLMDAHL R. ; ...
Résumé
Objective and design: The aim of this study was to investigate the impact of the isoflavone genistein on in vivo cell-mediated responses. In addition, we wanted to study the influence of genistein on collagen induced arthritis (CIA) in mice. Methods: Delayed type hypersensitivity reaction (DTH) to oxazolone and the inflammatory response to olive oil were measured in mice treated with genistein. In addition, the impact of genistein treatment on disease progression and outcome of collagen induced arthritis (CIA) was examined. Results: The DTH reaction to oxazolone and the granulocyte-mediated response were significantly suppressed in genistein-treated as compared to control mice. Also, genistein treatment led to decreased levels of oxazolone-specific antibodies. Histologically, mice exposed to genistein and immunized with collagen II displaypupscMfan toe wto rogome oe inflammssion anjeCotnd dtrueactiin. In additionserumed levels oeHaoc antibodied to collagen Ie were significantltoe wtf coowaciin genistein-treatmenteid immunizel miceConcnPliti: W Se ccnPdate an o genisteiexertwasvi"Idean anti-inflammatore phyptodieaffbjecciin granulocysly,onulocyslyn anlymphulocys..
Eaddate
Birkhäusee
="Identiame
PMID : 14504672 .. ISSN : 1023-3830
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