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Titre du Document
Relaxant effect of Foeniculum vulgare on isolated Guinea pig tracheal chains
Auteur(s)
BOSKABADY M. H. ; KHATAMI A.
Résumé
Foeniculum vulgare is a grassy plant which is believed to have several therapeutic effects including anti-asthmatic uses. We have therefore studied the relaxant (bronchodilatory) effect of this plant on isolated guinea pig tracheal chains and its possible mechanism(s). The bronchodilatory effects of aqueous and ethanol extracts. essential oil, and 1 μM theophylline in comparison with controls were examined by their relaxant effects on precontracted isolated tracheal chains of guinea pig in two different conditions including: non-incubated tissues (group 1) and incubated tissues with 1 μM propranolol and 1 μM chlorpheniramine (group 2). In addition, the anticholinergic effects of essential oil and 10nM atropine were tested by performing the cumulative log-concentration-response curves of methacholine induced contraction of tracheal chains compared with that of saline (for all experimental conditions n = 8). In group I and 2 experiments, essential oil and theophylline and, in group 1, ethanol extract showed significant relaxant effects compared to those of saline and ethanol, respectively. Although bronchodilatory effects of essential oil was lower than theophylline in group 1 (p < 0.01), there was no significant difference between the effect of ethanol extract in both groups and the effect of essential oil in group 2 experiments with that of theophylline. The relaxant effect obtained in group 2 for essential oil was significantly greater (p < 0.05) and for ethanol extract n
Editeur
Swets & Zeitlinger
Identifiant
ISSN : 1388-0209
Source
Pharmaceutical biology A. 2003, vol. 41, n° 3, pp. 211-215 [5 pages] [bibl. : 20 ref.]
Langue
Anglais
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