Détail de la notice
Titre du Document
The effects of acute cigarette smoking on cognitive functioning in chronic schizophrenia
Auteur(s)
TRACY J. I. ; MONACO C. ; GIOVANNETTI T. ; ...
Résumé
Introduction. The prevalence of cigarette smoking among patients with schizophrenia is high. Nicotine stimulates acetylcholine (ACh) transmission, and patients with schizophrenia may suffer from reduced ACh activity due to the combined effects of antipsychotic and antiparkinsonian drug treatment. The present study was designed to test whether cigarette smoking is, in part, an adaptive response among patients with schizophrenia to temporarily enhance cognitive functioning through an increase in ACh tone. Methods. Thirty-three inpatients with chronic schizophrenia treated with either clozapine (high in anticholinergicity) or risperidone (low anticholinergicity) were administrated a cognitive test battery under two experimental conditions : Acute Smocking and Abstinence. Results. Results showed a modest and fairly specific enhancement effect for smoking. During Acute Smoking a subset of patients on clopazine required less time to complete a test of attentional vigilance. Also, a significant interaction appeared such that subjects treated with clopazine demonstrated better discriminability under the Acute Smoking condition. Conclusions. The data are consistent with other findings suggesting a specific link between attentional functioning and nicotinic acetylcholine activity, and lend support to the cognitive enhancement hypothesis for cigarette smoking in terms of producing subtle benefits for selected functions in cognitively impaired schizophrenia patients who are experiencing
Editeur
Taylor and Francis
Identifiant
ISSN : 1354-6805
Source
Cognitive neuropsychiatry A. 2000, vol. 5, n° 3, pp. 193-217 [bibl. : 2 p.3/4]
Langue
Anglais
Pour les membres de la communauté du CNRS, ce document est autorisé à la reproduction à titre gratuit.
Pour les membres des communautés hors CNRS, la reproduction de ce document à titre onéreux sera fournie sous réserve d’autorisation du Centre Français d’exploitation du droit de Copie.

Pour bénéficier de nos services (strictement destinés aux membres de la communauté CNRS (Centre National de la Recherche Scientifique), de l'ESR français (Enseignement Supérieur et Recherche), et du secteur public français & étranger) :