Détail de la notice
Titre du Document
Carcinoma ductal infiltrante de mama. Diferencias clinicobiolÓgicas entre mujeres mayores de 70 años y aquéllas de entre 60 y 70 años
Clinical and biological differences between infiltrating ductal carcinomas of the breast in women over 70 years-old and those aged 60-70
Auteur(s)
RUIBAL Alvaro ; ARIAS José I. ; ALDECOA Belén
Résumé
BACKGROUND: There is discrepancy in the literature regarding the behavior of breast cancer in elderly women. For this reason we decided to study the possible clinical and biological differences of infiltrative ductal breast carcinoma between women over 70 years and those aged between 60 and 70 years. PATIENTS AND METHOD: The study group included 181 women with infiltrative ductal carcinomas (IDCs) who were referred from a breast clinic (BC) and a breast cancer screening campaign (BCS). 67 of them were older than 70 and 114 were between 60 and 70 years old. Estrogen receptors (ER), progesterone receptors (PR), pS2 and cathepsin D cytosolic levels were determined, as well as levels of epidermal growth factor receptor (EGFR) in cell surfaces. Likewise, size, axillary lymph node involvement, distant metastasis, histological grade, ploidy and cellular S-phase fraction were also considered as variables of the study. RESULTS: IDCs in women older than 70 had greater size (p<0.001), global S-phase (p = 0.009) and number of axillary lymph nodes involved (p = 0.002). Likewise, these tumors showed more frequently distant metastasis (p = 0.001) and S-phase values >14% (p = 0.093). However, when we considered only women referred from BCS, no differences in the parameters studied between women older than 70 and those aged between 60 and 70 years were observed. When only patients coming from BC were considered, women older than 70 had a greater number of axillary lymph nodes involved (p= 0.0
Editeur
Doyma
Identifiant
PMID : 12525308 ISSN : 0025-7753
Source
Medicina clinica (Ed. impresa) A. 2002, vol. 119, n° 20, pp. 761-764 [4 pages]
Langue
Espagnol
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