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Capsicum pain plaster in chronic non-specific low back pain
KEITEL Wolfgang ; FRERICK Helmut ; KUHN Ulrike ; ...
Topically applied capsaicin (CAS 404-86-4) induces the release of substance P, a neurotransmitter, from sensory C-fibres. In addition, there is a specific blockade of transport and de-novo synthesis of substance P. As a result, repeated applications of capsaicin bring about a long lasting desensitisation to pain (increase of pain threshold). The desensitising effect is fully reversible. The confirmed pharmacodynamic actions and a number of double-blind clinical studies indicate that local capsicum preparations are very suitable for the treatment of neuropathic pain or musculoskeletal disorders, with or without inflammatory components. In a double-blind, randomised parallel-group study a capsicum plaster was compared with a placebo for 3 weeks in 154 patients with non-specific back pain. Inclusion criteria were a history of back pain for a minimum period of 3 months and a degree of pain of 5 or more on an eleven grade visual analogue scale. The principal target variable consisted of the score of 3 combined pain scales. Secondary efficacy measures were tests of mobility, a disability index (in the context of Arhus low back rating scale) and global assessments by physicians and patients. For patients to be rated as responders their total pain score at the final examination after 3 weeks of treatment had to show a reduction by at least 30 % of the baseline value. The study unequivocally achieved the target criterion with a rate of responders in the capsicum group of 60.8 % agains
PMID : 11765591 ISSN : 0004-4172 CODEN : ARZNAD
Arzneimittel-Forschung A. 2001, vol. 51, n° 11, pp. 896-903 [bibl. : 60 ref.]
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