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Titre du Document
The concept of entero-colonic encephalopathy, autism and opioid receptor ligands
Auteur(s)
WAKEFIELD A. J. ; PULESTON J. M. ; MONTGOMERY S. M. ; ...
Résumé
There is growing awareness that primary gastrointestinal pathology may play an important role in the inception and clinical expression of some childhood developmental disorders, including autism. In addition to frequent gastrointestinal symptoms, children with autism often manifest complex biochemical and immunological abnormalities. The gut-brain axis is central to certain encephalopathies of extra-cranial origin, hepatic encephalopathy being the best characterized. Commonalities in the clinical characteristics of hepatic encephalopathy and a form of autism associated with developmental regression in an apparently previously normal child, accompanied by immune-mediated gastrointestinal pathology, have led to the proposal that there may be analogous mechanisms of toxic encephalopathy in patients with liver failure and some children with autism. Aberrations in opioid biochemistry are common to these two conditions, and there is evidence that opioid peptides may mediate certain aspects of the respective syndromes. The generation of plausible and testable hypotheses in this area may help to identify new treatment options in encephalopathies of extra-cranial origin. Therapeutic targets for this autistic phenotype may include: modification of diet and entero-colonic microbial milieu in order to reduce toxin substrates, improve nutritional status and modify mucosal immunity: anti-inflammatory/immunomodulatory therapy; and specific treatment of dysmotility, focusing, for example, on
Editeur
Blackwell
Identifiant
PMID : 11929383 ISSN : 0269-2813
Source
Alimentary pharmacology & therapeutics A. 2002, vol. 16, n° 4, pp. 663-674 [bibl. : 121 ref.]
Langue
Anglais
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