Détail de la notice
Titre du Document
Over-the-counter Δ5 anabolic steroids 5-androsten-3,17-dione; 5-androsten-3β, 17β-diol; dehydroepiandrosterone; and 19-nor-5-androsten-3,17-dione : Excretion studies in men
Auteur(s)
URALETS V. P. ; GILLETTE P. A.
Résumé
Studies of urinary steroids were performed in males after oral administration of 5-androsten-3,17-dione; 5-androsten-3β, 17β-diol; dehydroepiandrosterone; and 19-nor-5-androsten-3, 17-dione. 5-Androsten-3,17-dione; 5-androsten-3β,17β-diol; and dehydroepiandrosterone amplify most endogenous steroids, but to a lesser extent than their Δ4 analogues do. Especially affected are androsterone, etiocholanolone, dehydroandrosterone, dehydroepiandrosterone, and isomeric 5-androstendiols. 5-Androsten-3,17-dione; 5-androsten-3β,17β-diol; and dehydroepiandrosterone elevate the urinary testosterone to epitestosterone (T/E) ratio by a factor of 2-3 a few hours after administration. This may cause a positive T/E test (> 6) for individuals with normal T/E ratios higher than 2. Most of the steroids return to their original concentrations in less than 24 h. Etiocholanolone and 5β-androstan-3α,17β-diol remain elevated for several days. A reduced androsterone to etiocholanolone (A/E) ratio may be an indication of Δ5 steroids abuse. 19-Nor-5-androsten-3,17-dione has a similar effect, except that all metabolites in urine are 19-nor exogenous steroids. Identification criteria for 19-nor-5-androsten-3,17-dione may be the same as nandrolone, that is, detection of 19-norandrosterone and 19-noretiocholanolone. Specific abundant metabolites of 19-nor-5-androsten-3,17-dione are 19-nordehydroandrosterone and 19-nordehydroepiandrosterone. In the later stages of excretion, higher conce
Editeur
Preston
Type du document
Conférence : Cologne Workshop on Dope Analysis, 16, Cologne, DEU, 1999-03
Identifiant
PMID : 10774538 ISSN : 0146-4760 CODEN : JATOD3
Source
Journal of analytical toxicology A. 2000, vol. 24, n° 3, pp. 188-193 [bibl. : 8 ref.]
Langue
Anglais
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