Détail de la notice
Titre du Document
Phages and their application against drug-resistant bacteria
Auteur(s)
CHANISHVILI N. ; CHANISHVILI T. ; TEDIASHVILI M. ; ...
Résumé
At the beginning of the 20th century the phenomenon of spontaneous bacterial lysis was discovered independently by Twort and d'Herelle. Despite the suggestion at that time by d'Herelle that these agents might be applied to the control of bacterial diseases in the west this idea was explored in a desultory fashion only and was eventually discarded largely due to the advent of extensive antibiotic usage. However, interest was maintained in countries of the former Soviet Union where bacteriophage therapy has been applied extensively since that time. Central to this work was the Eliava Institute of Bacteriophage, Microbiology and Virology in Tbilisi, Georgia, which was founded in 1923 through the joint efforts of d'Herelle and the Georgian George Eliava. Ironically, given his contributions to public health in the Soviet Union, Eliava was branded as an enemy ofthe people in 1937 and executed, d'Herelle never again returned to Georgia. In spite of these tragic events this institute remained the focus for phage therapy in the world and despite being continuously active in this field for 75 years, now struggles for its financial life. In the Eliava Institute, phages were sought for bacterial pathogens implicated in disease outbreaks in different parts of the Soviet Union and were dispatched for use in hospitals throughout the country. Although infections caused by a wide variety of bacterial pathogens have been treated, much of this has been published in Russian and is not readily av
Editeur
Wiley
Type du document
Conférence : SCI Biotechnology Group. Meeting, London, GBR, 2000-07-13
Identifiant
ISSN : 0268-2575 CODEN : JCTBDC
Source
Journal of chemical technology and biotechnology (1986) A. 2001, vol. 76, n° 7, pp. 689-699 [bibl. : 69 ref.]
Langue
Anglais
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